English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   The invasive pulmonary aspergillosis is a kind of high incidence of disease with difficulties in treatment, poor prognosis, and high mortality.Objectives   The study aimed to reveal the effect of cinnamaldehyde on the fungal cell wall and verify its efficacy on invasive pulmonary aspergillosis on immunosuppressed Institute of Cancer Research mice (ICR mice).Methods   ICR mice were given cyclophosphamide 200 mg.kg −1 . d −1  by intraperitoneal injection for 2 days. On the 4th day, the mice were given 50  μL  of  Aspergillosis fumigatus  spore (10 7 colony form unit CFU/mL) by intranasal injection to establish immunosuppressive animal models with invasive  Aspergillosis fumigatus  infection. Then the mice in treatment group orally administered cinnamaldehyde for 14 consecutive days, while voriconazole was given to the mice in the positive control group.Results   The clearance rate of pulmonary fungi, cure rate, and reduction of 1,3- β - D -glucans in treatment group were 80.00%, 80.00%, and 81.00%, respectively while in positive control group they were 67.00%, 60.00%, and 62.00%, respectively. There were significant differences in the results between two groups as mentioned above (P<0.05). Electron microscopy showed that, in treatment group, the cell wall of  Aspergillus fumigatus  was dissolved and detached and the cell surface was incomplete. There were edema, degeneration, and necrosis in nucleus and organelle, which lead to cellular necrocytosis. The cytomembrane of  Aspergillus fumigatus  was intact, clear, and complete, whereas the cytomembrane in the positive control group disappeared. The hyphal morphology of  Aspergillus fumigatus  was deformed, but the cell wall was intact.Conclusion   Cinnamaldehyde has a good curative effect in the treatment of invasive pulmonary aspergillus infection in immunodeficient mice. It mainly affects the synthesis of 1,3- β - D -glucans from the cytoderm of  Aspergillus fumigatus  but does not affect cell wall. It would potentially be an effective and novel drug for targeted treatment of  Aspergillus fumigatus  deep infection.

Effects of Cinnamaldehyde on the Cell Wall ofA. fumigatusand Its Application in Treating Mice with Invasive Pulmonary Aspergillosis