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Although a number of studies have revealed the underlying mechanisms which regulate the development of colorectal cancer (CRC), we have not completely overcome this disease yet. Accumulating evidence has shown that the posttranscriptional regulation by the noncoding RNAs such as microRNAs plays an important role in the development or progression of CRC. Among a number of microRNAs, the  let-7  microRNA family that was first discovered in  C. elegans  and conserved from worms to humans has been linked with the development of many types of cancers including CRC. The expression level of  let-7  microRNAs is temporally low during the normal developmental processes, while elevated in the differentiated tissues. The  let-7  microRNAs regulate the cell proliferation, cell cycle, apoptosis, metabolism, and stemness. In CRC, expressions of  let-7  microRNAs have been reported to be reduced, and so  let-7  microRNAs are considered to be a tumor suppressor. In this review, we discuss the mechanisms regulating the  let-7  microRNA expression and the downstream targets of  let-7  in the context of intestinal tumorigenesis. The application of  let-7  mimics is also highlighted as a novel therapeutic agent.

The Molecular Basis and Therapeutic Potential ofLet-7MicroRNAs against Colorectal Cancer