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Cryptococcus gattii  is an etiologic agent of cryptococcosis and a serious disease that affects immunocompromised and immunocompetent patients worldwide. The therapeutic arsenal used to treat cryptococcosis is limited to a few antifungal agents, and the ability of  C. gattii  to form biofilms may hinder treatment and decrease its susceptibility to antifungal agents. The objective of this study was to evaluate the antifungal and antibiofilm activities of an ethanolic extract of  Cochlospermum regium  (Schrank) Pilger leaves against  C. gattii . The antifungal activity was assessed by measuring the minimum inhibitory concentration (MIC) using the broth microdilution technique and interaction of the extract with fluconazole was performed of checkerboard assay. The antibiofilm activity of the extract was evaluated in 96-well polystyrene microplates, and the biofilms were quantified by counting colony forming units. The extract showed antifungal activity at concentrations of 62.5 to 250  μ g/mL and when the extract was evaluated in combination with fluconazole,  C. gattii  was inhibited at sub-MIC levels. The antibiofilm activity of the extract against  C. gattii  was observed both during biofilm formation and on an already established biofilm. The results showed that the ethanolic extract of the leaves of  C. regium  shows promise for the development of antifungal drugs to treat cryptococcosis and to combat  C. gattii  biofilms.

Control ofCryptococcus GattiiBiofilms by an Ethanolic Extract ofCochlospermum Regium(Schrank) Pilger Leaves