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Justicia pectoralis  Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identify the phytochemical characterization and biological activities of  J. pectoralis  leaf extracts. The plant material was ground and the crude extracts were obtained with water or acetone: water (7:3 v/v), yielding aqueous (JPA), and organic (JPO) extracts. Phytochemical characterization was performed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and trypan blue (TB) exclusion assay in peripheral blood mononuclear cells (PBMCs), BALB/c splenocytes, and neoplastic cells (TOLEDO, K562, DU-145, and PANC-1) at 1, 10, and 100  μ g/mL. Antibacterial activity was evaluated using the microdilution test to obtain the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Cytokines, IFN- γ , and IL-17A from culture supernatants of BALB/c mice splenocytes were measured by sandwich ELISA. In the TLC analysis, both JPA and JPO extracts presented coumarin and flavonoids. In addition, HPLC was able to identify coumarin, apigenin, and ellagic acid in both extracts. JPO IC 50  was 57.59 ± 1.03  μ g/mL (MTT) and 69.44 ± 8.08  μ g/mL (TB) in TOLEDO. MIC value of JPO against  Acinetobacter baumannii  and  Klebsiella pneumoniae  was 500  μ g/mL. JPO (100  μ g/mL) significantly inhibited IFN- γ  levels (p=0.03).  J. pectoralis  is a potential candidate to be further investigated as an IFN- γ  inhibitory agent and against  Acinetobacter baumannii  and  Klebsiella pneumoniae .

evidence-based complementary and alternative medicine

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mtext mathvariant="bold">γ</mml:mtext></mml:mrow></mml:math> Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon-γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae