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In traditional Chinese medicine (TCM),  Acori Tatarinowii Rhizoma  ( ATR ) is widely used to treat memory and cognition dysfunction. This study aimed to confirm evidence regarding the potential therapeutic effect of  ATR  on Alzheimer's disease (AD) using a system network level based  in silico  approach. Study results showed that the compounds in  ATR  are highly connected to AD-related signaling pathways, biological processes, and organs. These findings were confirmed by compound-target network, target-organ location network, gene ontology analysis, and KEGG pathway enrichment analysis. Most compounds in  ATR  have been reported to have antifibrillar amyloid plaques, anti-tau phosphorylation, and anti-inflammatory effects. Our results indicated that compounds in  ATR  interact with multiple targets in a synergetic way. Furthermore, the mRNA expressions of genes targeted by  ATR  are elevated significantly in heart, brain, and liver. Our results suggest that the anti-inflammatory and immune system enhancing effects of  ATR  might contribute to its major therapeutic effects on Alzheimer's disease.

Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease