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Single-nucleotide polymorphisms (SNPs) in  MYH9-APOL1  gene regions have been reported to be associated with diabetic kidney disease (DKD) in the American population. We examined the association between polymorphisms in  MYH9-APOL1  and DKD susceptibility in a Chinese Han population.  MYH9  rs3752462 (T>C) and  APOL1  rs136161 (C>G) were genotyped in 303 DKD patients and 364 type 2 diabetes mellitus (T2DM) patients without kidney disease using the TaqMan SNP genotyping assay. Chi-squared test and multivariate logistic regression were used to evaluate the association. We observed that only  MYH9  rs3752462 was associated with DKD (genotype,  P  = 0.004; allele,  P  = 0.002). Genetic model analysis revealed that rs3752462 was associated with increased risk of DKD under a dominant model adjusted by age and sex (adjusted odds ratio (aOR), 1.675; 95% CI 1.225–2.289;  P  = 0.001) and an additive model (TC versus TT: aOR, 1.649; 95% CI 1.187–2.290; CC versus TT: aOR, 1.817; 95% CI 0.980–3.367;  P  = 0.005). The combined effect of rs3752462 TC + rs136161 CC genotype showed an association of DKD adjusted by age and sex (aOR, 1.732; 95% CI 1.128–2.660;  P  = 0.012). After a Holm-Bonferroni correction for multiple tests, the C allele frequencies of the rs3752462 and the TC + CC genotype in the dominant model were considered statistically significant with a markedly increased risk of DKD ( P  < 0.00208;  P  < 0.002). Our results suggest that  MYH9  rs3752462 is significantly associated with an increased risk of DKD in Chinese Han individuals.

journal of diabetes research

Association between<i>MYH9</i>and<i>APOL1</i>Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population

Association betweenMYH9andAPOL1Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population