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Aim   To clarify the association between the single nucleotide polymorphisms (SNPs) in the  NLRP1  and  NLRP3  and Psoriasis Vulgaris (PsV) in the Chinese Han population.Methods   We genotyped eight SNPs, four from  NLRP1  (rs8079034, rs11651270, rs11657747, and rs878329) and  NLRP3  (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls in the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and haplotype frequencies were analyzed using a case-control study design.Results   We identified two SNPs, rs3806265 and rs10754557, in  NLRP3  that were significantly associated with PsV. The genotype distribution of the rs3806265 SNP was significantly different between cases and controls ( p  = 0.0451; OR = 0.791; 95% CI = 0.627–0.998). In the recessive model, the genotype distribution of the rs10754557 SNP was significantly different between cases and controls ( p  = 0.0344; OR = 1.277; 95% CI = 0.987–1.652). The haplotype analysis of rs3806265 and rs10754557 also presented a significant association of TA haplotype with PsV ( χ  2  = 4.529;  p  = 0.033).Conclusion   NLRP3 may play a role in PsV susceptibility in the Chinese Han population.

Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population