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The present study was proposed to investigate the toxicological and prophylactic potential of ethanolic extracts of  Rosa damascena  and  Nymphaea alba  and their mixture in albino mice. For toxicity study, three different doses of plant extracts were orally administrated to three groups of mice for 14 successive days. Blood biochemistry and histological examinations of liver and kidney revealed that these extracts had no harmful effects up to 1000 mg/kg. To determine the prophylactic effects of  Rosa damascena ,  Nymphaea alba , and their mixture, an infection model of  Listeria monocytogenes  was established in a pilot study. Establishment of infection was confirmed by changes in haematological parameters and reisolation of  Listeria monocytogenes  from different tissues. Results showed that these extracts alone or in combination could restrict the growth of  Listeria monocytogenes  in different organs. Neutrophils were high in positive control group but remained in normal range in all treated groups.  Listeria monocytogenes  was recovered in low numbers from animals treated with extract of single plant but was negligible in group treated with mixture of extract of plants. Platelets count was increased in treated groups as compared to control. Results confirmed that these extracts are potent source of antimicrobial compounds and that they have synergistic effect in combined form.

Antilisterial Effect ofRosa damascenaandNymphaea albainMus musculus