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Lactobacillus plantarum , a probiotic, has a high survival rate and high colonization ability in the gastrointestinal tract. Tolerance to the gastrointestinal environment and adhesion to intestinal epithelial cells by some  Lactobacillus  species (excluding  L. plantarum ) are related to  luxS /AI-2. Here, the role of  luxS  in tolerance to simulated digestive juice (SDJ) and adhesion to Caco-2 cells by  L. plantarum  KLDS1.0391 (hereafter, KLDS1.0391) was investigated. The KLDS1.0391  luxS  mutant strain was constructed by homologous recombination. When  luxS  was deleted, acid and bile salt tolerance and survival rates in SDJ significantly decreased ( p  < 0.05 for all). The ability of the  luxS  deletion strain to adhere to Caco-2 cells was markedly lower than that of the wild-type strain ( p  < 0.05). The ability of the  luxS  mutant strain to adhere (competition, exclusion, and displacement) to  Escherichia coli  ATCC 25922 was significantly lower than that of the wild-type strain ( p  < 0.05 for all). A significant decrease was noted only in the exclusion adhesion inhibition of the  luxS  mutant strain to  Salmonella typhimurium  ATCC 14028 ( p  < 0.05). These results indicate that the  luxS  gene plays an important role in the gastrointestinal environment tolerance and adhesion ability of KLDS1.0391.

Role of luxS in Stress Tolerance and Adhesion Ability in Lactobacillus plantarum KLDS1.0391