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Although the tumorigenicity of asbestos, which is thought to cause mesothelioma, has been clarified, its effect on antitumor immunity requires further investigation. We previously reported a decrease in the percentage of perforin +  cells of stimulated CD8 +  lymphocytes derived from patients with malignant mesothelioma. Therefore, we examined the effects of long-term exposure to asbestos on CD8 +  T cell functions by comparing long-term cultures of the human CD8 +  T cell line EBT-8 with and without exposure to chrysotile (CH) asbestos as an  in vitro  model. Exposure to CH asbestos at 5  μ g/ml or 30  μ g/ml did not result in a decrease in intracellular granzyme B in EBT-8 cells. In contrast, the percentage of perforin +  cells decreased at both doses of CH exposure. CH exposure at 30  μ g/ml did not suppress degranulation following stimulation with antibodies to CD3. Secreted production of IFN- γ  stimulated via CD3 decreased by CH exposure at 30  μ g/ml, although the percentage of IFN- γ  +  cells induced by PMA/ionomycin did not decrease. These results indicate that long-term exposure to asbestos can potentially suppress perforin levels and the production of IFN- γ  in human CD8 +  T cells.

journal of immunology research

Decrease in Intracellular Perforin Levels and IFN-<i>γ</i> Production in Human CD8<sup>+</sup> T Cell Line following Long-Term Exposure to Asbestos Fibers

Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8+ T Cell Line following Long-Term Exposure to Asbestos Fibers

Decrease in Intracellular Perforin Levels and IFN-γ Production in Human CD8⁺ T Cell Line following Long-Term Exposure to Asbestos Fibers