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Aim   To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with  Bifidobacterium longum .Methods   Mice visceral hypersensitivity was induced by  Trichinella spiralis . After 8 weeks, they were divided into three groups (controls,  Bifidobacterium longum , and fecal microbiota transplantation) and were daily treated by gavage with 0.2 ml PBS,  Bifidobacterium longum  HB55020, or fecal microbiota for 7 days. Visceral hypersensitivity was tested with abdominal withdrawal reflex. Permeability of colon epithelium was assessed with Ussing chamber.Results   After administration of  Bifidobacterium longum , compared with mice in postinfectious group, mice had higher pain threshold ( p  < 0.05). After administration of fecal microbiota, compared with mice in postinfectious group, mice had higher pain threshold ( p  < 0.05). Fecal microbiota transplantation was as effective as  Bifidobacterium  in relieving visceral hypersensitivity. Administration of  Bifidobacterium longum  or fecal microbiota transplantation improved colon epithelium permeability. Expression of occluding-1 was increased.Conclusion   Manipulation of microbiota is effective in relieving visceral hypersensitivity. Fecal microbiota transplantation is as effective as  Bifidobacterium longum  administration.

Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model