English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The anti-inflammatory and antimicrobial properties of curcumin suggest its use as an anti- Helicobacter pylori  ( H. pylori ) agent, but mechanisms underlying its helpful activity are still not clear. Indoleamine 2,3-dioxygenase (IDO) promotes the effector T cell apoptosis by catalyzing the rate-limiting first step in tryptophan catabolism, and its high expression in  H. pylori -infected human gastric mucosa attenuates Th1 and Th17 immune response. The aim of this study was to investigate the role of curcumin in modulating the expression of IL-17 and IDO in  H. pylori -infected human gastric mucosa. In an organ culture chamber, gastric biopsies from 35 patients were treated with and without 200  μ M curcumin. In  H. pylori -infected patients ( n  = 21), IL-17 was significantly lower, both in gastric biopsies ( p  = 0.0003) and culture supernatant ( p  = 0.0001) while IDO significantly increased ( p  &lt; 0.00001) in curcumin-treated sample compared with untreated samples. In a subgroup of  H. pylori -infected patients ( n  = 15), samples treated with curcumin in addition to IDO inhibitor 1-methyl-L-tryptophan (1-MT) showed a higher expression of IL-17 compared with untreated samples and curcumin-treated alone ( p  &lt; 0.00001). Curcumin downregulates IL-17 production through the induction of IDO in  H. pylori -infected human gastric mucosa, suggesting its role in dampening  H. pylori -induced immune-mediated inflammatory changes.

journal of immunology research

Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards <i>Helicobacter pylori</i>

Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori