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Ferredoxin-NADP +  reductases (FNRs, EC 1.18.1.2) were found in the plastids of  Plasmodium  and have been considered as a target for the development of new antimalarial agents. Croomine,  epi -croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of  Stemona  sp. and their inhibitory effect on FNRs from  Plasmodium falciparum (Pf FNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from  Pf FNR to  Pf Fd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of  Pf FNR. Docking analysis represented that croomine is located at the middle position of  Pf FNR and  Pf Fd. Croomine from  S. tuberosa  appeared to have potential as an antimalarial agent.

Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites