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Escherichia coli  is responsible for a wide variety of community and hospital acquired extraintestinal infections, and the emergence of ESBL resistant isolates is a major clinical concern. In this study, we characterized the genomic attributes of an OXA-48 and CTX-M-3 producing  E. coli  EC-IMP153. Whole-genome initial assembly produced 146 contigs with a combined 5,504,170 bp in size and a G+C content of 50.5%. wgSNPs-based phylogenetic comparison with 36 publically available genomes was also performed. Comprehensive genomic analysis showed that EC-IMP153 belonged to sequence type ST-405 and harbored several resistance determinants including the  β -lactam resistance genes  bla  OXA-48 ,  bla  CTX-M-3 ,  bla  TEM-1B ,  bla  OXA-1 , and  bla  CMY-70 , aminoglycoside  fyuA  and  aac(3)IId , tetracycline  tet(A)  and  tet(R) , and fluoroquinolone  gyrA, parC,  and  mfd  resistance determinants. Plasmids with the following incompatibility groups were detected  in silico  and confirmed using PBRT: IncI1- α , IncL, IncW, Col (BS512), and IncF. To our knowledge this is the first in-depth genomic analysis of an OXA-48 producing  E. coli  ST-405 isolated from a patient in Lebanon and linked to a blood stream infection. Continuous monitoring is necessary to better understand the continued diffusion of such pathogens, especially in view of the population movements triggered by unrest in the Middle East.

biomed research international

Genomic Characterization of MDR Escherichia coli Harboring blaOXA-48 on the IncL/M-type Plasmid Isolated from Blood Stream Infection