English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background   Inadequate specialized cancer hospitals and high costs are contributing factors that delay cancer patients from accessing health care services in Tanzania. Consequently, majority of patients are first seen by Traditional Health Practitioners (THPs) before they access specialized services. This study presents ethnomedical information and preliminary evaluation of 25 plant species claimed by THPs in Mkuranga and Same districts of Tanzania on use for treatment of cancer. Literature search and laboratory investigation results are presented to support evaluation.Methods. This study was a single disease ethnomedical enquiry focusing on plants being used for cancer treatment   Face-to-face interviews and questionnaires were administered to  eight (8) THPs  in Mkuranga and Same districts on the claimed plants and their use for management of cancer. Plants were selected based on being frequently mentioned and emphasis given by THPs. Literature search and brine shrimp toxicity (BST) of methanol : dichloromethane (1:1) extracts was used as surrogates to evaluate strength of the claims.Results   This study reports 25 plant species used by the THPs in two districts of Tanzania. Eight plants (32%) have been reported in the literature to have activity against cancer cells. BST results revealed, 14 (56%) plants exhibited high toxicity against brine shrimps. The most active plants included  Croton pseudopulchellus  Pax (LC 50  4.2  μ g/ml),  Dalbergia melanoxylon  Guill. & Perr. (LC 50  6.8  μ g/ml),  Loranthus micranthus  Linn (LC 50  4.0  μ g/ml),  Ochna mossambicensis  Klotzsch (LC 50  3.3  μ g/ml), and  Spirostachys africana  Sond. (LC 50  4.4  μ g/ml); their toxicity was comparable to that of  Catharanthus roseus  (L) G. Don. (LC 50  6.7  μ g/ml), an established source of anticancer compounds. Nine other plants had LC 50  values between (19.8 and 71.6)  μ g/ml, indicating also potential to yield anticancer.Conclusion   Literature search and BST results provide a strong support of the potential of the claimed plants to yield active anticancer compounds.

Screening of Plants Used as Traditional Anticancer Remedies in Mkuranga and Same Districts, Tanzania, Using Brine Shrimp Toxicity Bioassay