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32 P high-dose rate brachytherapy allows high-dose radiation delivery to target lesions with less damage to adjacent tissues. The early evaluation of its therapeutic effect on tumours is vital for the optimization of treatment regimes. The most commonly used  32 P-CP colloid tends to leak with blind therapeutic area after intratumour injection. We prepared  32 P-chromic phosphate-polylactide-co-glycolide ( 32 P-CP-PLGA) seeds with biodegradable PLGA as a framework and investigated their characteristics  in vitro  and  in vivo . We also evaluated the therapeutic effect of  32 P-CP-PLGA brachytherapy for glioma with the integrin  α v β 3-targeted radiotracer  68 Ga-3PRGD 2 .  32 P-CP-PLGA seeds (seed group, SG, 185 MBq) and  32 P-CP colloid (colloid group, CG, 18.5 MBq) were implanted or injected into human glioma xenografts in nude mice. Scanning electron microscopy (SEM) of the seeds, micro-SPECT imaging, and biodistribution studies were performed at different time points. The tumour volume was measured using a caliper, and  68 Ga-3PRGD 2  micro-PET-CT imaging was performed to evaluate the therapeutic effect after  32 P intratumour administration. The delayed release of  32 P-CP was observed with biodegradation of vehicle PLGA. Intratumoural effective half-life of  32 P-CP in the SG (13.3 ± 0.3) d was longer than that in the CG (10.4 ± 0.3) d ( P  < 0.05), with liver appearance in the CG on SPECT. A radioactivity gradient developed inside the tumour in the SG, as confirmed by micro-SPECT and SEM. Tumour uptake of  68 Ga-3PRGD 2  displayed a significant increase on day 0.5 in the SG and decreased earlier (on day 2) than the volume reduction (on day 8). Thus,  32 P-CP-PLGA seeds, controlling the release of entrapped  32 P-CP particles, are promising for glioma brachytherapy, and  68 Ga-3PRGD 2  imaging shows potential for early response evaluation of  32 P-CP-PLGA seeds brachytherapy.

contrast media and molecular imaging/contrast media and molecular imaging

Investigation of Newly Prepared Biodegradable <sup>32</sup>P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

Investigation of Newly Prepared Biodegradable ³²P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy