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Background   To evaluate the clinical and prognostic value of PET/CT with combination of  68 Ga-DOTATATE and  18 F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).Method   83 patients of GEP-NENs who underwent  68 Ga-DOTATATE and  18 F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-differentiated (WD) NETs are divided into group A (Ki-67 < 10%) and group B (Ki-67 ≥ 10%), and poorly differentiated (PD) NECs are defined as group C. The relationship between PET/CT results and clinicopathological characteristics was retrospectively investigated.Result   For groups A/B/C, the sensitivities of  68 Ga-DOTATATE and  18 F-FDG were 78.8%/83.3%/37.5% and 52.0%/72.2%/100.0%. A negative correlation between Ki-67 and SUV max  of  68 Ga-DOTATATE ( R  = −0.415;  P  ≤ 0.001) was observed, while a positive correlation was noted between Ki-67 and SUV max  of  18 F-FDG ( R  = 0.683;  P  ≤ 0.001). 62.5% (5/8) of patients showed significantly more lesions in the bone if  68 Ga-DOTATATE was used, and 22.7% (5/22) of patients showed more lymph node metastases if  18 F-FDG was used.Conclusions   The sensitivity of dual tracers was correlated with cell differentiation, and a correlation between Ki-67 and both SUV max  of PET-CTs could be observed.  68 Ga-DOTATATE is suggested for WD-NET and  18 F-FDG is probably suitable for patients with Ki-67 ≥ 10%.

contrast media and molecular imaging/contrast media and molecular imaging

Clinical and Prognostic Value of PET/CT Imaging with Combination of <sup>68</sup>Ga-DOTATATE and <sup>18</sup>F-FDG in Gastroenteropancreatic Neuroendocrine Neoplasms

Clinical and Prognostic Value of PET/CT Imaging with Combination of 68Ga-DOTATATE and 18F-FDG in Gastroenteropancreatic Neuroendocrine Neoplasms

Clinical and Prognostic Value of PET/CT Imaging with Combination of ⁶⁸Ga-DOTATATE and ¹⁸F-FDG in Gastroenteropancreatic Neuroendocrine Neoplasms