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Evolution and spread of malaria parasite  Plasmodium falciparum  capable of evading antimalarials are the prime concern to malaria control. The currently effective drug, artemisinin (ART), is under threat due to detection of ART-resistant  P. falciparum  parasites in the Southeast Asian countries. It has been shown that amino acid (AA) mutations at the  P. falciparum Kelch13  ( Pfk13 ) gene provide resistance to ART. Nigeria, a part of the Sub-Saharan Africa, is highly endemic to malaria, contributing quite significantly to malaria, and resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) combination drugs has already been reported. Since artemisinin combined therapy (ACT) is the first-line drug for treatment of uncomplicated malaria in Nigeria and five amino acid mutations have been validated in the  Pfk13  gene alongside with candidate mutations for ART resistance, we performed molecular surveillance for mutations (following PCR and DNA sequence analyses) in this gene from two southwestern states of Nigeria. Statistical analyses of DNA sequences were also performed following different evolutionary models. None of the different validated and candidate AA mutations of  Pfk13  gene conferring resistance to ART could be detected in  P. falciparum  sampled in the two southwestern states of Nigeria. In addition, DNA sequencing and sequence analyses indicated neither evolutionary selection pressure on the  Pfk13  gene nor association of mutations in  Pfk13  gene with mutations of other three genes conferring resistance to CQ and SP. Therefore, based on the monomorphism at the  Pfk13  gene and nonassociation of mutations of this gene with mutations in three other drug-resistant genes in malaria parasite  P. falciparum , it can be proposed that malaria public health is not under immediate threat in southwestern Nigeria concerning ART resistance.

biomed research international

Status of Artemisinin Resistance in Malaria Parasite<i> Plasmodium falciparum</i> from Molecular Analyses of the<i> Kelch13</i> Gene in Southwestern Nigeria

Status of Artemisinin Resistance in Malaria Parasite Plasmodium falciparum from Molecular Analyses of the Kelch13 Gene in Southwestern Nigeria