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Glucocorticoids are a risk factor for age-induced skin structure and function defects, and the glucocorticoid-activating enzyme, 11 β -hydroxysteroid dehydrogenase 1 (11 β -HSD1), represents a promising therapeutic target.  Prunella vulgaris  L. (PV) is a perennial and an edible herbaceous plant normally cultivated in Asia and Europe. A recent study demonstrated a broad range of biological activities of PV including immune modulatory, antiviral, antiallergic, anti-inflammatory, antioxidant, and antidiabetic. However, little is known about the inhibitory effect of PV on 11 β -HSD1. In this study, we investigated the inhibitory effect of  Prunella vulgaris  L. extract (PVE) and the underlying mechanism of 11 β -HSD11 inhibition. Consistent with these results, cortisol levels were also reduced by PVE  in vitro . The cortisone-induced translocation of glucocorticoids receptor (GR) was also attenuated. In addition, PVE inhibited a cortisone-mediated decrease in collagen content in skin. Collectively, these results suggest the beneficial effects of PVE in maintaining skin integrity.

evidence-based complementary and alternative medicine

Inhibitory Effects of<i>Prunella vulgaris</i>L. Extract on 11<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-HSD1 in Human Skin Cells

Inhibitory Effects ofPrunella vulgarisL. Extract on 11β-HSD1 in Human Skin Cells