English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The tongue is a critical organ, involved in functions such as speaking, swallowing, mastication, and degustation. Although  Sox  genes are known to play critical roles in many biological processes, including organogenesis, the expression of the  Sox  family members during tongue development remains unclear. We therefore performed a comparative  in situ  hybridization analysis of 17  Sox  genes ( Sox1–14, 17, 18,  and  21 ) during murine tongue development.  Sox2, 4, 6, 8, 9, 10, 11, 12,  and  21  were found to be expressed in the tongue epithelium, whereas  Sox2, 4–6, 8–11, 13,  and  21  showed expression in the mesenchyme of the developing tongue. Expression of  Sox1, 4, 6, 8 – 12 , and  21  were observed in the developing tongue muscle.  Sox5  and  13  showed expression only at E12, while  Sox1  expression was observed only on E18.  Sox6, 8, 9 , and  12  showed expression at several stages. Although the expression of  Sox2 ,  4 ,  10 ,  11 , and  21  was detected during all the four stages of tongue development, their expression patterns differed among the stages. We thus identified a dynamic spatiotemporal expression pattern of the  Sox  genes during murine tongue development. To understand whether  Sox  genes are involved in the development of other craniofacial organs through similar roles to those in tongue development, we also examined the expression of  Sox  genes in eyelid primordia, which also contain epithelium, mesenchyme, and muscle. However, expression patterns and timing of  Sox  genes differed between tongue and eyelid development.  Sox  genes are thus related to organogenesis through different functions in each craniofacial organ.

SoxGenes Show Spatiotemporal Expression during Murine Tongue and Eyelid Development