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The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract from  Phoenix dactylifera  L. parthenocarpic dates. The antioxidant activity was carried using DPPH radical scavenging activity. The result showed that parthenocarpic dates had strongly scavenging activity on DPPH reaching 94% with an IC 50  value of 0.15 ± 0.011 mg/mL (p < 0.05). The anti-inflammatory potential was determined by the inhibitory effect of the aqueous ethanolic extract on phospholipase A 2  activity as well as on carrageenan-induced paw oedema in mice. The  in vitro  study showed that the extract inhibited the phospholipase A 2  activity with an IC 50  value of 130  μ g/mL and the  in vivo  study showed a significantly decrease in the paw oedema after 1 h compared to the control group. Finally, the antiproliferative activity of the aqueous ethanolic extract was assessed by MTT test against MCF-7 and MDA-MB-231 cancer cell lines. This extract was effective in inhibiting MDA-MB-231 and MCF-7 cancer cells growth with IC 50  values of 8 and 18 mg/mL, respectively, after 72 h treatment. These results confirm the ethnopharmacological significance of  Phoenix dactylifera  L. parthenocarpic dates, which could add support for its pharmaceutical use.

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract fromPhoenix dactyliferaL. Parthenocarpic Dates