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The effect of topical application of ointment based on  Strychnos pseudoquina  hydroethanolic extract in the cutaneous wounds healing in diabetic rats was evaluated. Samples of  S. pseudoquina  were submitted to phytochemical prospection and  in vitro  antioxidant assay. Thirty Wistar rats were divided into 5 groups: Sal-wounds treated with 0.9% saline solution; VH-wounds treated with 0.6 g of lanolin cream (vehicle); SS-wounds treated with silver sulfadiazine cream (10 mg/g); ES5- and ES10-wounds treated with an ointment of  S. pseudoquina  extract, 5% and 10%, respectively. Fragments of wounds were removed for histological and biochemical analysis every 7 days during 21 days. ES showed equivalent levels per gram of extract of total phenols and flavonoids equal to 122.04 mg for TAE and 0.60 mg for RE. The chlorogenic acid was one of the major constituents.  S. pseudoquina  extract presented high antioxidant potential  in vitro . ES5 and ES10 showed higher wound healing rate and higher amount of cells, blood vessels, and type III and I collagen. The oxidative stress markers were lower in the ES5 and ES10 groups, while the antioxidants enzymes levels were higher. Ointment based on  S. pseudoquina  extract promotes a fast and efficient cutaneous repair in diabetic rats.

biomed research international

Hydroethanolic Extract of<i> Strychnos pseudoquina</i> Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes

Hydroethanolic Extract of Strychnos pseudoquina Accelerates Skin Wound Healing by Modulating the Oxidative Status and Microstructural Reorganization of Scar Tissue in Experimental Type I Diabetes