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Antroquinonol was investigated as antioxidant and inhibition of inflammatory responses. Our study was to evaluate its immunosuppressive effect on CD8 +  T cells and protective effect on depigmentation. CD8 +  T cells were treated with antroquinonol  in vitro , and C57BL/6 mice were treated with antroquinonol with or without H 2 O 2    in vivo  for 50 consecutive days. We found antroquinonol could inhibit proliferation of CD8 +  T cells and suppress the production of cytokines IL-2 and IFN- γ  and T cell activation markers CD69 and CD137  in vitro . H 2 O 2  treatment induced depigmentation and reduced hair follicle length, skin thickness, and tyrosinase expression  in vivo . Whereas, antroquinonol obviously ameliorated depigmentation of mice skin and resisted the reduction of hair follicle length, skin thickness, and tyrosinase expression induced by H 2 O 2 . Antroquinonol decreased CD8 +  T cell infiltration in mice skin, inhibited the production of IL-2 and IFN- γ , and decreased the expression of CXCL10 and CXCR3. Summarily, our data shows antroquinonol inhibits CD8 +  T cell proliferation  in vitro . It also reduces CD8 +  T cell infiltration and proinflammatory cytokine secretion and suppresses the thinning of epidermal layer  in vivo . Our findings suggest that antroquinonol exerts immunosuppressive effects on CD8 +  T cell proliferation and activation to resist depigmentation induced by H 2 O 2 .

oxidative medicine and cellular longevity

Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2