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Fine particulate matter (PM 2.5 ) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70). Furthermore, PM 2.5  increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles. We investigated whether moderate and high intensity training under exposure to low levels of PM 2.5  modifies heart OS and the eHSP70 to iHSP70 ratio (H-index), a biomarker of inflammatory status. Male mice ( n  = 32), 30 days old, were divided into six groups for 12 weeks: control (CON), moderate (MIT) and high intensity training (HIT), exposure to 5  μ g of PM 2.5  daily (PM 2.5 ), and moderate and high intensity training exposed to PM 2.5  (MIT + PM 2.5  and HIT + PM 2.5  groups). The CON and PM 2.5  groups remained sedentary. The MIT + PM 2.5  group showed higher heart lipid peroxidation levels than the MIT and PM 2.5  groups. HIT and HIT + PM 2.5  showed higher heart lipid peroxidation levels and lower eHSP70 and H-index levels compared to sedentary animals. No alterations were found in heart antioxidant enzyme activity or iHSP70 levels. Moderate exercise training under exposure to low levels of PM 2.5  induces heart OS but does not modify eHSP70 to iHSP70 ratio (H-index). High intensity exercise training promotes anti-inflammatory profile despite exposure to low levels of PM 2.5 .

Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio