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Periostracum cicadae  is widely used for the treatment of skin diseases such as eczema, pruritus, and itching. The current study sought to evaluate the effect of  P. cicadae  extract on ultraviolet B (UVB) irradiation and identify the mechanisms involved. Photodamage-protective activity of  P. cicadae  extracts against oxidative challenge was screened using HaCaT keratinocytes.  P. cicadae  extracts did not affect cell viability but decreased reactive oxygen species (ROS) production. The extract attenuates the expression of interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), and MMP-9 in UVB-treated HaCaT cells. Also,  P. cicadae  abrogated UVB-induced activation of NF- κ B, p53, and activator protein-1 (AP-1). The downmodulation of IL-6 by  P. cicadae  was inhibited by the p38 inhibitor (SB203580) or JNK inhibitor (SP600125). Moreover, the extract attenuated the expression of NF- κ B and induced thrombomodulin in keratinocytes and thereby effectively downregulated inflammatory responses in the skin. The nuclear accumulation and expression of NF-E2-related factor (Nrf2) were increased by  P. cicadae  treatment. Furthermore, treatment with  P. cicadae  remarkably ameliorated the skin's structural damage induced by irradiation. This study demonstrates that  P. cicadae  may protect skin cells against oxidative insult by modulating ROS concentration, IL-6, MMPs generation, antioxidant enzymes activity, and cell signaling pathways.

Extract fromPeriostracum cicadaeInhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes