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Background and Aim   The specific association between genetic variation and in-stent restenosis is still only partly understood. The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF- β 1; rs1800470) and target lesion revascularization (TLR) risk.Methods   A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included. The primary study endpoint was TLR at a 4-year follow-up.Results   The TLR rate was higher in patients with the  VEGFA  A/A genotype (15.4%) than in patients with the  VEGFA  A/C (7.9%) and C/C (8.9%) genotypes ( p  = 0.009). The  VEGFA  A/A genotype, after adjustment for clinical and procedural covariates, remained significantly and independently associated with the TLR (hazard ratio—2.09 [95% confidence interval 1.32–3.33,  p  = 0.0017]). However, we found no association between TLR and the  TGFB1  genotype.Conclusion   The  VEGFA  A/A genotype is significantly and independently associated with TLR risk in Polish SCAD patients who received elective PCI with bare-metal stent implantation.

The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention