English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Calotropis procera  is traditionally used for treating many diseases including ulcers and tumors. It was thus deemed of interest to investigate and compare the antiulcer and cytotoxic activities of  C. procera  leaf, flower, and fruit extracts in an attempt to verify its traditional uses. Phytochemical studies on the fruits, flowers, and leaves of  C. procera,  collected from the desert of Saudi Arabia, led to the isolation of one new lignan 7′-methoxy-3′- O -demethyl-tanegool-9- O - β - d -glucopyranoside and five known compounds from the flowers, four compounds from leaves, and a flavonoid glycoside and a lignan glycoside from the fruits. The structures of compounds were determined by spectroscopic techniques. Ethanol extracts of the three parts of  C. procera  were evaluated for their antiulcer activity and we found that the leaf extract possessed a powerful antiulcer activity which could be considered as a promising drug candidate. All the extracts and the isolated compounds were evaluated for their cytotoxic activity against MCF-7, HCT-116, HepG-2, and A-549 human cancer cell lines. Compound  2  was highly active on all the cell lines, whereas compounds  5  and  11  were more selective on colon and liver cell lines. Compound  10  demonstrated a significant activity on liver and lung cancer cell lines.

evidence-based complementary and alternative medicine

Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of<i>Calotropis procera</i>and Isolation of a New Lignan Glycoside

Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts ofCalotropis proceraand Isolation of a New Lignan Glycoside