English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Five medicinal plants of Pakistan were investigated for their antinociceptive, anti-inflammatory, antidepressant, and anticoagulant potential. Antinociceptive activity was estimated by hot plate and writhing assay. In hot plate assay,  Quercus dilatata  (52.2%) and  Hedera nepalensis  (59.1%) showed moderate while  Withania coagulans  (65.3%) displayed a significant reduction in pain. On the other hand, in writhing assay,  Quercus dilatata  (49.6%),  Hedera nepalensis  (52.7%), and  Withania coagulans  (62.0%) showed comparative less activity. In anti-inflammatory assays crude extracts showed significant edema inhibition in a dose dependent manner. In carrageenan assay, the highest activity was observed for  Withania coagulans  (70.0%) followed by  Quercus dilatata  (66.7%) and  Hedera nepalensis  (63.3%). Similar behavior was observed in histamine assay with percentage inhibitions of 74.3%, 60.4%, and 63.5%, respectively. Antidepressant activity was estimated by forced swim test and the most potent activity was revealed by  Withania coagulans  with immobility time 2.2s (95.9%) followed by  Hedera nepalensis  with immobility time 25.3s (53.4%). Moreover, the crude extracts of  Fagonia cretica  (74.6%),  Hedera nepalensis  (73.8%), and  Phytolacca latbenia  (67.3%) showed good anticoagulant activity with coagulation times 86.9s, 84.3s, and 67.5s, respectively. Collectively, the results demonstrate that these five plants have rich medicinal constituents which can be further explored.

Five Indigenous Plants of Pakistan with Antinociceptive, Anti-Inflammatory, Antidepressant, and Anticoagulant Properties in Sprague Dawley Rats