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Background   Curcumin contained in  Curcuma xanthorrhiza  is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D 3  is expected to work synergistically.Objective   To determine the effect of  Curcuma xanthorrhiza  supplementation on vitamin D 3  administration to SLEDAI, IL-6, and TGF- β 1 serum in SLE patients with hypovitamin D.Methods   This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016–March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and  Curcuma xanthorrhiza  3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF- β 1 in serum were evaluated before and after the treatment.Results   There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF- β 1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction.  Conclusion. Curcuma xanthorrhiza  supplementation on vitamin D 3  had no effects on SLEDAI and serum levels of IL-6 and TGF- β 1. This clinical trial is registered with  NCT03155477 .

international journal of rheumatology

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum