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In an attempt to identify herbal drugs which may become useful in the prevention of diabetes, antioxidant potentials and  α -amylase inhibition by the ethanol extracts of two plants belonging to Lamiaceae family,  Otostegia persica  and  Zataria multiflora , and their different fractions were studied. Also, inhibition of  α -amylase by  Salvia mirzayanii  and its fractions was evaluated. All of the samples exhibited antioxidant activities, among which ethyl acetate fraction of  Zataria multiflora  (17.21 ± 0.17 mg GAE/g) was found to contain the highest amounts of phenols and the ethyl acetate fraction of  Zataria multiflora  (218 ± 2.76 mg QUE/g) had the most values of flavonoids. Ethyl acetate fraction of  Zataria multiflora  (IC 50  = 3.05 ± 0.51  μ g/ml) was shown to have the most reducing power and the ethyl acetate fraction of  Zataria multiflora  (IC 50  = 32.17 ± 1.82  μ g/ml) exhibited the highest DPPH radical scavenging. The ethyl acetate fraction of  Otostegia persica  (99.39 ± 0.94%) showed the highest  α -amylase inhibitory activity which was similar to acarbose used as a standard. Mode of  α -amylase inhibition of the most samples was uncompetitive except for  ZMC ,  OPP ,  OPC , and  SMP  which presented competitive inhibition. The present findings showed that studied samples may have some compounds with antioxidant and antidiabetic effects.

biomed research international

Evaluation of Antioxidant Potentials and <i>α</i>-Amylase Inhibition of Different Fractions of Labiatae Plants Extracts: As a Model of Antidiabetic Compounds Properties

Evaluation of Antioxidant Potentials and α-Amylase Inhibition of Different Fractions of Labiatae Plants Extracts: As a Model of Antidiabetic Compounds Properties