English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background   The inflammatory response directed against  Helicobacter pylori  ( HP ) is believed to be one of the main triggers of the appearance of gastric lesions and their progression to gastric cancer (GC). Epstein-Barr virus (EBV) has been found responsible for about 10% of all GCs, but the inflammatory response has not been studied in GC patients with evidence of high levels of EBV reactivation.Objective   To determine the relationship between inflammation and antibodies against EBV reactivation antigens,  HP , and the bacterium virulence factor CagA in patients with GC.Methods   127 GC patients, 46 gastritis patients, and 197 healthy subjects were studied. IL-1 β , IL-6, IL-8, IL-10, TNF- α , TGF- β , MCP-1, and IFN- γ  levels were measured in serum or plasma and compared against the antibody titers of VCA-IgG,  HP , and the  HP  virulence factor CagA. Statistical associations were estimated.Results   Significant ORs and positive trends were found between VCA-IgG and IFN- γ , specifically for patients with GC of intestinal type (OR: 6.4, 95% C.I. 1.2–35.4) ( p  < 0.044).Conclusions   We confirmed a positive association between a marker of EBV reactivation and intestinal gastric cancer and present evidence of a correlation with elevated serum levels of IFN- γ , but not with the other cytokines.

journal of immunology research

Elevated Levels of Interferon-<i>γ</i> Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer

Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer