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Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM  Yin-cold (YC)  or  Yang-heat (YH)  syndrome types and the  EGFR  gene status, we prospectively studied 310 NSCLC patients. TCM  YH  or  YC  was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between the  EGFR  gene status,  YH  or  YC  syndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had their  EGFR  gene tested, 45.24%  YC  (76/168) and 25.95%  YH  (34/131) patients had  EGFR  mutations ( p  = 0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar to  YC , whereas 160 group B patients were similar to  YH . In the 281 patients with  EGFR  tested, 45.67% group A (58/127) and 28.57% group B patients (44/154) had  EGFR  mutations ( p  = 0.003). The  EGFR  status was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients with  YC  were more likely to have  EGFR  gene mutations.

evidence-based complementary and alternative medicine

<i>Yin-Cold</i> or<i> Yang-Heat</i> Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept

Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept