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Background   MicroRNA (miRNA) dysregulation was commonly seen in papillary thyroid carcinoma (PTC), and  miR-195  was verified to be downregulated in PTC by the large data set analysis from The Cancer Genome Atlas (TCGA). Our study aimed to explore the biological functions and the underlying molecular mechanisms of  miR-195  in PTC.Methods   The relative expression of  miR-195  and its target genes were assessed by quantitative RT-PCR assay in 38 pairs of PTC and the adjacent thyroid tissues. Assays were performed to evaluate the effect of  miR-195  on the proliferation, migration, and invasion in PTC cell lines. Moreover, we searched for targets of  miR-195  and explored the possible molecular pathway of  miR-195  in PTC.Results   We found that  miR-195  was downregulated in PTC cell lines and tissues. Overexpression of  miR-195  significantly inhibited cell proliferation, migration, and invasion in K1 and BCPAP cell lines.  CCND1  and  FGF2 , which had inverse correlations with  miR-195  in clinical specimens, were found to be the direct targets of  miR-195 . Furthermore,  miR-195  might be involved in PTC tumorigenesis by suppressing the Wnt/ β -catenin signaling pathway.Conclusions   These results highlight an important role of  miR-195  in the initiation and progression of PTC and implicate the potential application of  miR-195  in PTC target therapy.

MiR-195Inhibits Tumor Growth and Metastasis in Papillary Thyroid Carcinoma Cell Lines by TargetingCCND1andFGF2