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Objective   This study aimed to explore the immunoregulatory effect of flavonoids of blueberry ( Vaccinium corymbosum  L.) leaves (FBL).Methods   The flavonoids of blueberry leaves were prepared with 70% ethanol and were identified by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-Tof-MS). The immunoregulatory effect and possible regulatory mechanisms of FBL were investigated in lipopolysaccharide- (LPS-) induced RAW 264.7 cells.Results   According to the results of UPLC/Q-Tof-MS, nine flavonoids of blueberry leaves were identified. FBL showed a significant reduction in the production of TNF- α  in LPS-stimulated RAW 264.7 cells. FBL significantly decreased the expression of NF- κ B p65 and P-NF- κ B p65 in LPS-induced RAW 264.7 cells in a dose-dependent manner.Conclusion   Our study showed the immunoregulatory effect of FBL through the suppression of TNF- α  via the NF- κ B signal pathway.

journal of immunology research

Immunomodulatory Effect of Flavonoids of Blueberry (<i>Vaccinium corymbosum</i> L.) Leaves via the NF-<i>κ</i>B Signal Pathway in LPS-Stimulated RAW 264.7 Cells

Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells