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Background   Around 70–90% of peptic ulcer disease (PUD) is due to  Helicobacter pylori  and requires treatment with antimicrobials to which these bacteria are susceptible. Common  H. pylori  diagnostic tests do not provide drug susceptibility data. Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous detection of  H. pylori  and its resistance to clarithromycin (CLA)/fluoroquinolones (FLQ), we present evidence for stool as an optional test specimen and also provide data on prevalence of  H. pylori  resistance to CLA and FLQ in Uganda.Methods   Stool from 142 symptomatic PUD patients at three hospitals in Kampala was screened for  H. pylori  using a rapid antigen test. The GenoType HelicoDR test was run on all  H. pylori  antigen positives to determine PCR positivity and resistance to CLA/FLQ.Results   Thirty-one samples (22%) were  H. pylori  antigen positive, and 21 (68%) of these were  H. pylori  PCR positive. Six of the 21 (29%) were resistant to CLA and eight to FLQ (42%), while two gave invalid FLQ resistance results.Conclusion   Stool is a possible specimen for the GenoType HelicoDR test for rapid detection of  H. pylori  and drug resistance. In Uganda,  Helicobacter pylori  is highly resistant to CLA and FLQ.

biomed research international

<i>Helicobacter pylori</i> from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool

Helicobacter pylori from Peptic Ulcer Patients in Uganda Is Highly Resistant to Clarithromycin and Fluoroquinolones: Results of the GenoType HelicoDR Test Directly Applied on Stool