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An efficient synthesis of milnacipran hydrochloride has been accomplished. The important application of this paper is the reductive amination of aldehyde to primary amine with water soluble reagents. This method provides a high yield of primary amine as the major product, reduces the number of steps, and discourages by-products

An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde