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Antcin-H, a natural triterpene, is purified from a famous anticancer medicinal mushroom,  Antrodia cinnamomea,  in Taiwan. This study showed that antcin-H inhibited the growth of human renal carcinoma 786-0 cells; the IC 50  value (for 48 h) was 170  μ M. Besides, the migration and invasion of 786-0 cells were suppressed by antcin-H under noncytotoxic concentrations (<100  μ M); these events were accompanied by inhibition of FAK and Src kinase activities, decrease of paxillin phosphorylation, impairment of lamellipodium formation, and upregulation of TIMPs and downregulation of MMPs, especially MMP-7 expression. Luciferase reporter assay showed that antcin-H repressed the MMP-7 promoter activity, in parallel to inhibiting c-Fos/AP-1 and C/EBP- β  transactivation abilities. Moreover, antcin-H suppressed the activity of ERK1/2 and decreased the binding ability of C/EBP- β  and c-Fos on the upstream/enhancer region of MMP-7 promoter. Overall, this study demonstrated that the anti-invasive effect of antcin-H in human renal carcinoma 786-0 cells might be at least in part by abrogating focal adhesion complex and lamellipodium formation through inhibiting the Src/FAK-paxillin signaling pathways and decreasing MMP-7 expression through suppressing the ERK1/2-AP-1/c-Fos and C/EBP- β  signaling axis. Our findings provide the evidence that antcin-H may be an active component existing in  A. cinnamomea  with anticancer effect.

evidence-based complementary and alternative medicine

Antcin-H Isolated from<i>Antrodia cinnamomea</i>Inhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-<i>β</i>/c-Fos-MMP-7 Pathways

Antcin-H Isolated fromAntrodia cinnamomeaInhibits Renal Cancer Cell Invasion Partly through Inactivation of FAK-ERK-C/EBP-β/c-Fos-MMP-7 Pathways