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Purpose   To confirm its dose-dependent effect on form deprivation myopia and evaluate the effect of MT3 at different tissue concentrations on changes in mRNA and protein expression for TGF- β 2 and HAS2.Methods   MT3 was intravitreally injected into deprived eyes at two-day intervals. Refraction was measured by streak retinoscopy after cycloplegia. The axial dimensions were measured by A-scan ultrasound. The quantitative RT-PCR and Western blot were used to detect the changes of TGF- β 2 and HAS2 expressions in the retina and choroid of guinea pigs.Results   MT3 treatment produced a significant dose-dependent reduction in relative myopia compared to FD group (both  p  < 0.001). There were statistically significant increases in retinal and choroidal mRNA levels for both TGF- β 2 and HAS2 after injections of 10  μ M of MT3, when compared to the FD group. There were no significant differences in retinal and choroidal TGF- β 2 protein expression levels between the MT3 treatment groups and FD group (all  p  > 0.05). The injections of 10  μ M of MT3 caused a marked decrease in retinal HAS2 protein expression level, when compared to the FD group ( p  = 0.001).Conclusion   MT3 can inhibit form deprivation myopia, and MT3 treatment can result in changes of retinal and choroidal TGF- β 2 and HAS2 mRNA and protein expressions.

Effect of MT3 on Retinal and Choroidal TGF-β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig