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This study was designed to investigate the antifungal activity of a hydroalcoholic extract from  Flos Rosae Chinensis  (FRC) combined with fluconazole (FCZ) against clinical isolates of  Candida albicans  resistant to FCZ. The minimum inhibitory concentration (MIC) of FRC was determined using a checkerboard microdilution assay. The synergistic effects of the combination of FRC and FCZ against clinical isolates of  C. albicans  resistant to FCZ were further confirmed by constructing time-growth curves and performing an agar diffusion test. FRC alone exerted efficient antifungal activities against  C. albicans  within a MIC 80  ranging from 20  μ g/ml to 40  μ g/ml. FRC failed to enhance the effects of FCZ against sensitive  C. albicans  strains, although it rendered FCZ-resistant  C. albicans  more sensitive. These results were further confirmed by the result of in vivo study. Our study is the first to discover that FRC can inhibit the growth of  C. albicans  to a certain degree. An FRC antifungal mechanism study showed that FRC strengthens FCZ to inhibit the action of ergosterol biosynthesis by promoting the transformation of lanosterol to eburicol, suggesting that the antifungal mechanism of FRC involves the inhibition of ergosterol biosynthesis.

Antifungal Activity of the Ethanol Extract fromFlos Rosae Chinensiswith Activity against Fluconazole-Resistant ClinicalCandida