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Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy. Women with a GDM history are at increased risk of developing diabetes and cardiovascular diseases. Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors. The aim of this study was to investigate the relationship between clinical parameters in GDM and variants in genes involved with nutrients and metabolism. Several variants  PPARG2  rs1801282 ( C>G );  PPARGC1A  rs8192678 ( C>T );  TCF7L2  rs7903146 ( C>T );  LDLR  rs2228671 ( C>T );  MTHFR  rs1801133 ( C>T );  APOA5  rs662799 ( T>C );  GCKR  rs1260326 ( C>T );  FTO  rs9939609 ( T>A );  MC4R  rs17782313 ( T>C ) were genotyped in 168 pregnant Caucasian women with or without GDM by High Resolution Melting (HRM) analysis. A significant correlation was observed between TT genotype of  TCF7L2  gene and increased risk of GDM (OR 5.4 [95% CI 1.5–19.3]). Moreover, a significant correlation was observed between lipid parameters and genetic variations in additional genes, namely,  PPARG2  [ p  = 0,02],  APOA5  [ p  = 0,02],  MC4R  [ p  = 0,03],  LDLR  [ p  = 0,01], and  FTO  [ p  = 0,02]. Our findings support the association between  TCF7L2  rs7903146 variant and an increased GDM risk. Results about the investigated genetic variants provide important information about cardiometabolic risk in GDM and help to plan future prevention studies.

journal of diabetes research

Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women