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Objective   To investigate the association of single-nucleotide polymorphisms (SNPs) in  SP110  gene and  TNF-α  gene among pulmonary TB (PTB) and spinal TB (STB) patients.Methods   In a total of 190 PTB patients, 183 STB patients were enrolled as the case group and 362 healthy individuals at the same geographical region as the control group. The  SP110  SNPs (rs722555 and rs1135791) and the promoter -308G>A (rs1800629) and -238G>A (rs361525) polymorphisms in  TNF-α  were genotyped.  Results. TNF - α  -238G>A polymorphism was involved in susceptibility to STB, but not to PTB. The  TNF - α  -238 A allele was a protective factor against STB (A versus G: OR [95% CI] = 0.331 [0.113–0.972],  P  = 0.044). Furthermore, the presence of the -238 A allele was considered a trend to decrease the risk of STB (AG versus GG:  P  = 0.062, OR [95% CI] = 0.352 [0.118–1.053]; AA + AG versus GG:  P  = 0.050, OR [95CI%] = 0.335 [0.113–0.999]). However,  SP110  SNPs (rs722555 and rs1135791) and  TNF-α  -308G>A (rs1800629) showed no association with PTB and STB in all genetic models.Conclusion   The  TNF-α  -238 A allele appeared a protective effect against STB, whereas the  SP110  SNPs (rs722555 and rs1135791) and  TNF-α  -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.

Polymorphisms in theSP110andTNF-αGene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population