English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose   Dental caries is a multifactorial infectious disease. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene were associated with susceptibility to permanent tooth caries in Chinese adolescents.Method   A total of 200 dental caries patients and 200 healthy controls aged 12 years were genotyped for  VDR  gene polymorphisms using the PCR-restriction fragment length polymorphism (PCR-RFLP) assay. All of them were examined for their oral and dental status with the WHO criteria, and clinical information such as the Decayed Missing Filled Teeth Index (DMFT) was evaluated. Genomic DNA was extracted from the buccal epithelial cells. The four polymorphic SNPs ( Bsm  I,  Taq  I,  Apa  I, and  Fok  I) in  VDR  were assessed for both genotypic and phenotypic susceptibilities.Results   Among the four examined  VDR  gene polymorphisms, the increased frequency of the CT and CC genotype of the  Fok  I  VDR  gene polymorphism was associated with dental caries in 12-year-old adolescent, compared with the controls ( X  2  = 17.813,  p  ≤ 0.001). Moreover,  Fok  I polymorphic allele C frequency was significantly increased in the dental caries cases, compared to the controls ( X  2  = 14.144,  p  ≤ 0.001, OR = 1.730, 95% CI = 1.299–2.303). However, the other three  VDR  gene polymorphisms ( Bsm  I,  Taq  I, and  Apa  I) showed no statistically significant differences in the caries groups compared with the controls.ConclusionVDR-Fok  I gene polymorphisms may be associated with susceptibility to permanent tooth caries in Chinese adolescent.

biomed research international

Association between Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Polymorphisms and Permanent Tooth Caries Susceptibility to Permanent Tooth Caries in Chinese Adolescent