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The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of  Dissotis multiflora  (Sm) Triana  (D. multiflora)  on  Shigella flexneri -induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 10 9  cells/mL  S. flexneri  to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days' subacute toxicity.  S. flexneri  stool load decreased significantly in dose-dependent manner. The level of ALT increased ( p  < 0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease ( p  < 0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of  D. multiflora . Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that  D. multiflora  leaf extract is efficient against diarrhea caused by  S. flexneri  but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation