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The IFN- λ 3 gene  (IFNL3)  plays a role in HCV clearance. We investigated circulating IFN- λ 3 and  IFNL3  SNPs in haemodialysis patients who differed in their response to HBV vaccination and their HBV/HCV infection status. In 201 patients, plasma IFN- λ 3 was determined using ELISA.  IFNL3  SNPs (rs12979860, rs8099917) were genotyped using HRM analysis. Differences in IFN- λ 3 levels were shown between responders and nonresponders to HBV vaccination and between HBsAg-positive patients and those who developed anti-HBs after infection and became HBsAg negative. HBV vaccine responders without HCV resolution revealed lower IFN- λ 3 than noninfected responders. HBsAg/HCV RNA-positive subjects showed lower IFN- λ 3 than patients positive only for HCV RNA or subjects who resolved both infections. Circulating IFN- λ 3 correlated positively with anti-HBs and negatively with positive HCV RNA testing in the adjusted regression analyses. HBV vaccine nonresponders, HBsAg-positive patients, and subjects with replicating HCV composed a group with unfavourable outcomes. Responders to HBV vaccination, subjects who became HBsAg negative, and those who cleared HCV were analysed as having favourable outcomes. The latter showed higher IFN- λ 3 but did not differ in distribution of  IFNL3  SNPs compared with subjects with unfavourable outcomes. Higher IFN- λ 3 concentrations are associated with response to HBV vaccination, self-limited HBV infection, and HCV resolution.

Circulating Interferon-λ3, Responsiveness to HBV Vaccination, and HBV/HCV Infections in Haemodialysis Patients