English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was designed to identify some bioactive phytochemicals from ethanolic extract of roots of  Litsea polyantha  and to evaluate some of its pharmacological activities. Phytochemical tests indicated the presence of reducing sugar, combined reducing sugar, tannins, flavonoids, alkaloids, terpenoids, and phenol. In the antioxidant assay using 2-diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging method, the IC 50  value was found to be 82.31  μ g/mL. Total content of phenolic compounds, flavonoid, and tannin was found to be 152.69 mg GAE/gm, 85.60 mg QE/gm, and 77.22 mg GAE/gm of dry extract, respectively. In disc diffusion antibacterial assay, the extract exhibited highest zone of inhibition up to 12.25 mm against  Escherichia coli  at the concentration of 500  μ g/disc. For brine shrimp lethality bioassay, the extract exhibited LC 50  56.082  μ g/mL. In  in vivo  antihyperglycemic activity test by oral glucose tolerance test using  Swiss Albino  mice at the oral dose of 250 and 500 mg/kg, the extract showed statistically significant antihyperglycemic effect. Finally,  in vivo,  the extract exhibited the dose dependent CNS depressant effects by reducing the locomotors of  Swiss Albino  mice which was confirmed through three different neuropharmacological activity tests such as open field, hole cross, and hole board test.

evidence-based complementary and alternative medicine

Screening of Natural Bioactive Metabolites and Investigation of Antioxidant, Antimicrobial, Antihyperglycemic, Neuropharmacological, and Cytotoxicity Potentials of<i>Litsea polyantha</i>Juss. Ethanolic Root Extract

Screening of Natural Bioactive Metabolites and Investigation of Antioxidant, Antimicrobial, Antihyperglycemic, Neuropharmacological, and Cytotoxicity Potentials ofLitsea polyanthaJuss. Ethanolic Root Extract