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Background   Hypertension, including essential and secondary hypertension, is a multifactorial disease, affecting more than one billion people worldwide. Secondary hypertension can result from mutations of cullin-3 ( CUL3 ); however, whether polymorphisms of  CUL3  are associated with essential hypertension (EH) has not been reported. Here, we investigated the association between  CUL3  SNPs rs17479770 and rs3738952 and EH in the Chinese Han population.Methods   This case-control study investigated 520 representatives, including 259 patients with EH and 261 normotensive controls matched for age, gender, BMI, TG, TC, and HbA1c for the distribution of functional rs17479770 and rs3738952 within the  CUL3  gene by using PCR and RFLP.Results   Our results showed that there was no significant difference in allele and genotype distribution of rs3738952 and haplotype distribution of rs17479770 and rs3738952 between the EH group and normotensive group, whereas the rs17479770 TT genotype in male and the full data set were significantly associated with the decreased risk of EH ( P  = 0.050,  P  = 0.042), and rs17479770 allele T in male was shown to have the correlation tendency of the decreased risk of EH ( P  = 0.064).Conclusion   Our data suggest that the  CUL3  rs17479770 variant could be a protective factor in the pathogenesis of EH.

Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population