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Optical tomography is an emerging and important molecular imaging modality. The aim of optical tomography is to reconstruct optical properties of human tissues. In this paper, we focus on reconstructing the absorption coefficient based on the radiative transfer equation (RTE). It is an ill-posed parameter identification problem. Regularization methods have been broadly applied to reconstruct the optical coefficients, such as the total variation (TV) regularization and the  L  1  regularization. In order to better reconstruct the piecewise constant and sparse coefficient distributions, TV and  L  1  norms are combined as the regularization. The forward problem is discretized with the discontinuous Galerkin method on the spatial space and the finite element method on the angular space. The minimization problem is solved by a Jacobian-based Levenberg-Marquardt type method which is equipped with a split Bregman algorithms for the  L  1  regularization. We use the adjoint method to compute the Jacobian matrix which dramatically improves the computation efficiency. By comparing with the other imaging reconstruction methods based on TV and  L  1  regularizations, the simulation results show the validity and efficiency of the proposed method.

computational and mathematical methods in medicine

Mixed Total Variation and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mi>L</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">1</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math> Regularization Method for Optical Tomography Based on Radiative Transfer Equation

Mixed Total Variation and L1 Regularization Method for Optical Tomography Based on Radiative Transfer Equation