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The complexes  cis -[Ru(quin)(dppm) 2 ]PF 6  and  cis -[Ru(kynu)(dppm) 2 ]PF 6  (quin = quinaldate; kynu = kynurenate; dppm =  bis (diphenylphosphino)methane) were prepared and characterized by elemental analysis, electronic, FTIR,  1 H, and  31 P{ 1 H} NMR spectroscopies. Characterization data were consistent with a  cis  arrangement for the dppm ligands and a bidentate coordination through carboxylate oxygens of the quin and kynu anions. These complexes were not able to intercalate CT-DNA as shown by circular dichroism spectroscopy. On the other hand, bovine serum albumin (BSA) binding constants and thermodynamic parameters suggest spontaneous interactions with this protein by hydrogen bonds and van der Waals forces. Cytotoxicity assays were carried out on a panel of human cancer cell lines including HepG2, MCF-7, and MO59J and one normal cell line GM07492A. In general, the new ruthenium(II) complexes displayed a moderate to high cytotoxicity in all the assayed cell lines with IC 50  ranging from 10.1 to 36  µ M and were more cytotoxic than the precursor  cis -[RuCl 2 (dppm) 2 ]. The  cis -[Ru(quin)(dppm) 2 ]PF 6  were two to three times more active than the reference metallodrug cisplatin in the MCF-7 and MO59J cell lines.

bioinorganic chemistry and applications/bioinorganic chemistry and applications

Synthesis, Characterization, Cytotoxic Activity, and Interactions with CT-DNA and BSA of Cationic Ruthenium(II) Complexes Containing Dppm and Quinoline Carboxylates