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Infection by  Treponema pallidum  still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.

Subacute Hypophysitis with Panhypopituitarism as First Presentation of HIV and Syphilis Coinfection