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Sakuranetin is flavonoid phytoalexin that serves as a plant antibiotic and exists in  Prunus  and several other plant species. Recently, we identified the anti-inflammatory effect of  Prunus yedoensis  and found that there were few studies on the potential anti-inflammatory activity of sakuranetin, one of the main constituents of  Prunus yedoensis . Here, we isolated peritoneal macrophages from thioglycollate-injected mice and examined whether sakuranetin affected the response of the macrophages in response to lipopolysaccharide (LPS) plus interferon- (IFN-)  γ  or LPS only. Sakuranetin suppressed the synthesis of iNOS and COX2 in LPS/IFN- γ  stimulated cells and the secretion of TNF- α , IL-6, and IL-12 in LPS stimulated cells. The surface expression of the costimulatory molecules, CD86 and CD40, was also decreased. Among the LPS-induced signaling molecules, STAT1, JNK, and p38 phosphorylation was attenuated. These findings are evidence that sakuranetin acts as anti-inflammatory flavonoid and further study is required to evaluate its  in vivo  efficacy.

Sakuranetin Inhibits Inflammatory Enzyme, Cytokine, and Costimulatory Molecule Expression in Macrophages through Modulation of JNK, p38, and STAT1